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Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice.

Fujiwara H, Yamazaki T, Uzawa A, Nagata K, Kobayashi Y

Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1, Miyama, Funabashi, Japan.

IL-10 is known to suppress the inflammatory responses in a variety of experimental models. Because we previously found that whole-body X-irradiation causes massive apoptosis in the thymus and transient infiltration of neutrophils, in this study, we examined whether or not IL-10 is involved in the regulation of neutrophil infiltration upon whole-body X-ray irradiation using IL-10 knockout mice. Although IL-10 was induced in the thymus on whole-body X-ray irradiation, apoptosis of thymocytes, neutrophil infiltration, and MIP-2 and KC production in the thymus were not affected by an IL-10 deficiency. Coculturing of bone marrow-derived macrophages with late apoptotic cells caused MIP-2 production, which was also not affected by an IL-10 deficiency. These results suggest the uniqueness of the inflammatory response induced by whole-body X-ray irradiation, which does not seem to be regulated by IL-10.

Published 25 March 2008 in Biochem Biophys Res Commun, 369(2): 432-6.
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