Radiotherapy Research Today is a free monthly online journal that collates and summarizes the latest research about Radiotherapy, including details on cancer treatment, side effects.

Current management and challenges of malignant disease in the CNS in paediatric leukaemia.

Pui CH, Howard SC

Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38015-2794, USA. ching-hon.pui@stjude.org

With 5-year event-free survival of 80% now commonplace for paediatric acute lymphoblastic leukaemia (ALL), and 50% for paediatric acute myeloid leukaemia (AML), recent efforts have focused on optimum risk-directed treatment. Because cranial irradiation can cause many acute and late complications (eg, second cancers, neurocognitive deficits, endocrine disorders, and growth impairment), it has been largely replaced by intensive intrathecal treatment and systemic chemotherapy. Prophylactic cranial irradiation (12-18 Gy) is given to 2-20% of patients with ALL who have an increased risk of CNS relapse (such as T-cell immunophenotype, overt CNS disease, high-risk cytogenetic features, or poor response to remission induction treatment), and for the estimated 2% of patients with AML who have overt CNS disease at diagnosis. Although this strategy restricts CNS relapse to 3-8% of patients, several challenges remain. Methods need to eliminate relapse without the use of cranial irradiation in very high-risk patients. Effective retrieval treatment is needed for patients with relapsed or refractory CNS leukaemia, and intrathecal treatment with improved efficacy and reduced side-effects remains a long-term objective. Perhaps the most formidable challenge is to treat children with CNS relapse after a short initial remission or cranial irradiation.

Published 29 February 2008 in Lancet Oncol, 9(3): 257-68.
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