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An analysis of an implantable dosimeter system for external beam therapy.

Black RD, Scarantino CW, Mann GG, Anscher MS, Ornitz RD, Nelms BE

Sicel Technologies, Morrisville, NC 27560, USA. bblack@siceltech.com

BACKGROUND AND PURPOSE: To review the data from an implantable radiation dosimetry system used in a clinical setting and to examine correlations between dosimeter readings and potential causative error sources. MATERIALS AND METHODS: MOSFET (metal oxide semiconductor field effect transistor) based encapsulated dosimeters were evaluated in a phantom (in vitro) and in a study with 18 patients. The dosimeters were placed in the gross tumor volume or in collateral normal tissue. Predicted dose values were established by imaging the dosimeters in the planning CTs. RESULTS: The in vitro study confirmed that bounding cumulative errors due to setup, planning, and machine output within a +/-5% level is achievable. In patients, it was found that deviations from the targeted dose often exceeded the 5% level. CONCLUSIONS: The use of an implantable dosimeter system could provide an effective empiric check on the dose delivered at depth. Such a tool may have value for institutional quality assurance, as well as for therapy delivered to individual patients.

Published 22 August 2005 in Int J Radiat Oncol Biol Phys, 63(1): 290-300.
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